Israeli troops killed 10 Palestinians Wednesday in a raid on the occupied West Bank city of Nablus, while more than 80 suffered gunshot wounds, the Palestinian health ministry said.
The Israeli army said the raid targeted militant suspects "in a hideout apartment" accused of shootings in the West Bank, and that its troops came under live fire but suffered no casualties.
Top Palestinian official Hussein Al Sheikh decried the incursion as a "massacre" and called for "international protection for our people".
The death toll is equal to that of an Israeli army raid last month in Jenin, further north, which was the deadliest West Bank operation since at least 2005.
The Israeli military said that all three targeted suspects in the Nablus operation were "neutralised", either while fleeing the building or in an "exchange of fire".
"Armed suspects shot heavily toward the forces, who responded with live fire," said the military, adding that rocks, explosive devices and Molotov cocktails were thrown at the troops.
The Palestinian health ministry said those killed "as a result of the occupation's aggression on Nablus" were aged between 16 and 72.
A further 82 people were admitted to multiple hospitals with gunshot wounds, Palestinian health officials said.
Huge crowds gathered outside Nablus's Rafidia hospital, waiting for news of dozens of casualties being treated at the facility.
The wounded include Palestine TV journalist Mohammed Al Khatib, who was shot in the hand, his colleague told AFP.
The Islamic Jihad militant group said one of its commanders was killed "in a heroic battle against the Israeli occupation army and its special forces".
The Lions' Den, a local band of fighters, said six of those killed were militants from various factions.
Troops withdrew from the city after three hours, an AFP journalist said.
The Palestinian Red Crescent Society said its medics had treated 250 cases of tear gas inhalation and dozens of gunshot wounds.
The Arab League said the raid amounted to a "heinous crime".
"The occupation authorities and the far-right Israeli government are responsible for this horrible massacre," said Saeed Abu Ali, the Arab League's assistant secretary-general for Palestinian affairs.
The latest deadly Israeli incursion follows an appeal by the United Nations Middle East peace envoy, Tor Wennesland, for the violence to be halted as an "urgent priority".
"We have seen ominous signs of what awaits if we fail to address the current instability," he told the UN Security Council on Monday.
Since the start of this year, the Israeli-Palestinian conflict has claimed the lives of 59 Palestinian adults and children, including militants and civilians.
Nine Israeli civilians, including three children, one Ukrainian civilian and a police officer have been killed over the same period, according to an AFP tally based on official sources from both sides.
US Secretary of State Antony Blinken spoke Saturday with Israeli Prime Minister Benjamin Netanyahu and separately with Palestinian president Mahmud Abbas, calling both to "restore calm".
Last month's visit by Washington's top envoy to Israel and the Palestinian territories has been followed by further violence and rifts between officials.
Israel has occupied the Palestinian territory since the Six-Day War of 1967.
Last year was the deadliest year in the territory since the United Nations started tracking casualties in 2005.
© Agence France-Presse
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